What is 4-ANDRO?
4-ANDRO is an unmethylated synthetic prohormone, which means it is not toxic to the liver.
4-ANDRO or 4-DHEA is for all intents and purposes a precursor to the quintessential male hormone, testosterone.
A small amount is also synthesized peripherally from specific precursors (dehydroepiandrosterone and 17-hydroxyprogesterone).
In general, it is more similar to the chemical structure of testosterone than 1-androsterone (1-Andro).
It also serves as a weak potential androgen receptor agonist.
Tuttavia, come pro-ormone, si converte in testosterone grazie all’enzima 3-beta idrossisteroide deidrogenasi (3bHSD).
Although the bioavailability is rather poor, it is still better than that of 1-Androstenedione.
In addition, the half-life of 4-Andro is relatively short.
Consequently, large and frequent doses are required to notice results (more information, below).
Being for all intents and purposes a testosterone precursor, users who have taken 4-ANDRO have reported all the effects of taking testosterone:
- Increased lean muscle mass
- Increased strength
- Improved sex drive
- Improved quality of sleep
- Improved energy and concentration
- Improved self-esteem
However, the side effects are also those typical of testosterone:
- Possible side effects:
- Hair loss ( if predisposed)
- Acne ( if predisposed)
- Possible gynecomastia
- Worsening of cholesterol levels.
4-Andro is a prohormone generally available in liquid or capsule form.
4-ANDRO converts 15% to 25% into testosterone.
This means that if we take 100mg of 4-ANDRO, our body will convert 15 to 25mg into testosterone.
When we make the necessary proportions, we can see how an intake of 100mg per day of 4-ANDRO corresponds to an intake of testosterone from TRT (testosterone replacement therapy).
Having a relatively short half-life, the ideal method of intake is to divide the daily intake into two separate and equal doses.
In the world of “bodybuilding enhanced” 4-ANDRO lends itself as the best solution for creating a “testosterone base” during a SARMS cycle.
Of course, PCT is required at the end of the cycle.
In conclusion, it is interesting to note that some TRT users successfully experiment with taking 4-ANDRO in oral form as a replacement for classic testosterone enanthate via intramuscular injection.