In recent years, interest

in SARMs has grown exponentially in the fitness and bodybuilding world.

This phenomenon can be attributed primarily to the promise of improvements in body composition, strength, and endurance, with a potentially more limited side effect profile than traditional anabolic steroids.

One of the most common questions among those approaching the world of SARMs for the first time concerns the choice of the most suitable products and the proper setting of an initial cycle.

It is natural to have many doubts, especially considering that there are no official medical guidelines or universally recognized protocols.

The information available is often informational and based on empirical references, mostly found on forums or online communities.

However, it is crucial to remember that any decision should be made with awareness and, preferably, with the support of a physician or health professional.

What SARMs are?

SARMs are synthetic compounds designed to selectively bind to androgen receptors, promoting muscle growth and improved bone density with fewer systemic side effects than traditional anabolic steroids.

The goal is to act in a targeted manner, reducing the impact on unwanted organs and tissues.

Importantly, clinical research on SARMs is still limited, many products on the market do not undergo adequate quality control, and the long-term effects on humans remain largely unknown

Those approaching SARMs for the first time ask themselves several questions. Among the most common ones are:

Which SARMs to choose to get started?

The choice depends on personal goals and level of experience.

Those approaching the world of SARMs for the first time have as their main goal experiencing the products safely, avoiding significant side effects, and gaining enough muscle mass to make a difference in the gym.

Approaching SARMs requires responsibility, knowledge, and a constant focus on safety.

Although they can be a potential resource for physical improvement, it is essential to use them judiciously and always with an eye to one’s health.

An early round of SARMs often mentioned in the literature includes the joint use of Ostarine (MK-2866), Cardarine (GW501516) and Enclomiphene.

This combination is sometimes presented as a “soft” initial strategy for those approaching such substances for the first time.

The idea behind this combination is to take advantage of the potential benefits of each compound:

• Ostarine: Promote the growth of lean muscle mass.
• Cardarine: Improve endurance and promote fat loss.
• Enclomiphene: Mitigate or prevent hormone suppression by keeping the HPTA (hypothalamus-pituitary-testicle) axis active.

First Cycle of SARMs

Let us now look in detail at how the molecules generally used for a first cycle of Sarms act.

1. Ostarine (MK-2866)

• Benefits:
  Moderate increase in lean muscle mass, improved recovery, maintenance of muscle during caloric deficit phase.
• Unofficial dosage cited online:
  20 mg/day.
• Considerations:
  Ostarine is often seen as the “gateway” into the world of SARMs, believed to be less aggressive on endogenous testosterone. However, data on safety and tolerability remain limited.

2. Cardarine (GW501516)

• Benefits:
  Improved endurance, increased aerobic capacity, fat loss support.
• Unofficial dosage cited online:
  20 mg/day.
• Considerations: Cardarina is not technically a SARM, but a PPAR-delta agonist. Cardarina is popular among users of these molecules for its potential effects on lipid metabolism, body composition (fat oxidation), and increased endurance.

3. Enclomiphene

• Benefits:
  Stimulating endogenous testosterone production, supporting the hormone axis, potentially avoiding or reducing the need for Post Cycle Therapy (PCT).
• Unofficial dosage cited online: 12.5 mg/day.
• Considerations: An isomer of clomiphene, Enclomiphene aims to stimulate the hypothalamus and pituitary gland, keeping the HPTA axis active, without the troublesome side effects of clomiphene.

Why these three substances together?

On a theoretical level, the combination of Ostarine and Cardarina aims to create synergy in improving body composition and performance:

• Ostarine: to support the development and maintenance of lean muscle mass.
• Cardarine: to increase cardiovascular endurance and promote fat loss.

The addition of Enclomiphene aims to maintain endogenous testosterone production, preventing hormone suppression and making PCT unnecessary.

Ostarine: A gentle introduction to SARMs

Ostarine is considered to be one of the “gentler” choices for those new to SARMs. This is because it presents:

• Moderate safety profile:
  Compared with other SARMs, such as RAD-140 or YK-11, Ostarine is less aggressive on nonmuscle androgen receptors. This reduces the risk of systemic side effects.
• Gradual benefits:
  Promotes moderate gains in lean muscle mass and facilitates physical recovery, making it ideal for an initial approach.
• Low hormone suppression:
  Although not free from effects on the HPTA (hypothalamus-pituitary-testicle) axis, testosterone suppression is often minimal compared to more potent molecules such as Ligandrol (LGD-4033).

Compared with “stronger” SARMs, Ostarine represents a compromise between efficacy and safety, allowing investigators to assess their bodies’ tolerance.

 

Cardarine: An aid for endurance and fat loss

Although not technically a SARM, Cardarina is often included in cycles for its complementary effects on endurance and body composition.

• Cardiovascular support:
  Improves fat oxidation and aerobic capacity, factors that can help in both strength and cardiovascular workouts.
• Metabolic improvement:
  Cardarin is known to promote the use of fat as an energy source, promoting more efficient fat loss.
• Less invasive profile:
  Compared with molecules such as classical steroids (e.g., Clenbuterol), Cardarina does not act directly on the hormonal axis, reducing the risk of endocrine suppression.

 

Enclomiphene: Protection of the hormone axis.

A major concern in the use of SARMs is the suppression of endogenous testosterone. The inclusion of Enclomiphene in the cycle aims to:

• Stimulate testosterone production:
  Enclomiphene acts on the hypothalamus and pituitary gland to promote the release of gonadotropins (LH and FSH), which are critical for testosterone production.
• Prevent complete suppression:
  Enclomiphene significantly reduces the risk of hormone imbalance.
• Reduce the need for PCT:
  By keeping the HPTA axis partially active during the cycle, the need for full Post Cycle Therapy (PCT) can be minimized or eliminated.

Compared to other solutions, such as the use of more invasive drugs for PCT (e.g., HCG or pure Clomiphene), Enclomiphene is a more manageable option for first-time experimenters.

Advantages over more impactful molecules

The use of Ostarine, Cardarin, and Enclomiphene offers several advantages over other more impactful molecules, such as anabolic steroids or more potent SARMs:

• Safety profile:
  Molecules such as RAD-140, LGD-4033, or steroids such as Dianabol have a much higher risk of side effects, including complete testosterone suppression, liver damage, and cardiovascular alterations.
• Graduality of results:
  The first cycle is often considered a learning moment for those experimenting with these substances. Ostarine and Cardarin offer gradual benefits that allow monitoring of tolerance and the body’s reactions.
• Hormonal maintenance:
  The inclusion of Enclomiphene helps mitigate the risk of severe endocrine imbalances, a common problem with more impactful molecules.
• Less psychological impact: The more gradual effects of this combination reduce the risk of psychological dependence, which can be more pronounced with more potent anabolic steroids or SARMs.

The first cycle based on Ostarine, Cardarin and Enclomiphene is often chosen for its combination of moderate efficacy and a relatively manageable safety profile. Although not without risk, this combination represents a less invasive alternative to more potent molecules or traditional steroids.

However, it is critical to remember that the use of these substances still carries real health risks. Medical supervision is essential to minimize the dangers and ensure that any imbalances are managed promptly. In any case, it is always preferable to rely on safe, legal, and sustainable methods for improving physical performance and body composition.

Cycle length and dosage considerations

Some unofficial sources suggest cycles of 8-12 weeks, with dosages of:

• Ostarine and Cardarine: 20 mg/day
• Enclomiphene: 12.5 mg/day

Individual responses can vary significantly, and there is no “formula” that applies to everyone.

 

Medical and legal aspects

• Medical advice:
  Before considering the use of SARMs or similar compounds, it is essential to consult a physician, especially if there are pre-existing health conditions.
• Legal and sports aspects:
  Many SARMs are banned by major anti-doping agencies, such as WADA. The use of such substances can lead to sports disqualifications, legal penalties and damage to the athlete’s image.

 

Conclusions

The proposal of a “first cycle” of SARMs with Ostarine, Cardarin and Enclomiphene is sometimes presented as a moderate initial approach to improve body composition, performance and keep the hormonal axis active.

However, this scenario is supported by limited scientific data and has real health risks, as well as potential legal and sporting consequences.

This article is in no way intended to promote the use of SARMs or other doping substances without medical supervision, but only to provide general information.