In recent years, SARMs
(Selective Androgen Receptor Modulators) have gained popularity among athletes, bodybuilders and fitness enthusiasts, so much so that they are considered by some to be “the new steroids.”
But how much truth is there in this claim?
In this article, we will explore the benefits and potential side effects of the most popular SARMs available in our catalog: SARM Ostarine (Enobosarm), SARM CP-105, RAD-140 (Testolone), LGD-4033 (Ligandrol), Cardarina(technically not a SARM), SARM LGD-3303, YK-11, and SARM S-23.
What are SARMs?
SARMs are compounds designed to selectively bind to androgen receptors in muscle and bone tissues.
Unlike anabolic steroids, which affect the whole body, SARMs aim to provide anabolic effects while reducing the risks of systemic side effects such as gynecomastia or severe liver damage.
However, as we shall see, they are not completely risk-free.
Ostarine (Enobosarm)
Benefits:
Ostarine is one of the most popular and studied SARMs.
It is prized for its ability to promote muscle growth and improve strength while reducing the risk of muscle loss during a low-calorie diet.
It is often chosen by beginners because of its relatively mild side effect profile.
Side effects:
- Mild (temporary) suppression of endogenous testosterone
- Possible increase in liver enzymes (rare)
SARM ACP-105
Benefits:
ACP-105 is known to be one of the SARMs with a rapid and potent anabolic profile.
It improves bone density and recovery, making it ideal for those seeking rapid support during intense workouts.
Side effects:
- Moderate testosterone suppression (temporary)
- Possible gastrointestinal upset
- Possible increase in liver enzymes (rare)
SARM RAD-140 (Testolone)
Benefits:
RAD-140 is often considered one of the most potent SARMs for muscle growth.
It is a common choice for those who want a safer alternative to anabolic steroids, with notable benefits in strength and endurance.
Side effects:
- High testosterone suppression (temporary)
- Possible insomnia and nervousness
- Possible alterations in cholesterol levels
- Possible increase in liver enzymes
SARM LGD-4033 (Ligandrol)
Benefits:
LGD-4033 is one of the most popular SARMs for its ability to promote significant muscle gains and dramatically increase strength.
It is also known for its ability to improve bone health and density.
Side effects:
- Significant suppression of testosterone (temporary)
- Possible adverse effects on cholesterol
- Water retention
Cardarine (Endurobol)
Benefits:
Although technically not a SARM but a PPAR-delta receptor agonist, Cardarina is often included in cycles for its ability to improve cardiovascular endurance and oxidize fat.
Side effects:
- A study in mice raised concerns about potential carcinogenic effects (it was discovered that the study was done with nonsensical dosages and with 2 years of consecutive intake, whereas a cycle of caradrine lasts 8/10 weeks at most).
- Possible increase in oxidative stress
SARM LGD-3303
Benefits:
LGD-3303 is less well known than Ligandrol but promises similar muscle growth with less potential for side effects. It is still being studied for the treatment of osteoporosis and sarcopenia.
Side effects:
- Testosterone suppression (temporary)
- Lack of long-term data
SARM YK-11
Benefits:
YK-11 is unique among SARMs, being a myostatin inhibitor.
This makes it particularly effective for unlocking maximum muscle growth potential.
It is considered an advanced SARM, suitable for experienced users.
Side effects:
- Significant testosterone suppression (temporary)
- Possible liver toxicity
SARM S-23
Benefits:
S-23 is one of the most potent and anabolic SARMs.
It is often used for recomposition cycles, offering significant muscle gains with fat loss.
Side effects:
- Very marked suppression of testosterone (temporary)
- Alterations in cholesterol levels and liver enzymes
- Possible temporary reduction in fertility
SARMs represent an attractive option for those seeking more targeted alternatives to anabolic steroids. However, they are not without risks.
SARMs vs Steroids: The Comparison
In this section, we will compare each SARM with a commonly used steroid, highlighting its specific benefits to help you make an informed choice.
Ostarine (Enobosarm) vs Anavar (Oxandrolone)
Similarities:
Ostarine and Anavar share the ability to preserve muscle mass during periods of caloric restriction, making them ideal for cutting cycles.
Both have moderate anabolic effects, promoting cleaner muscle definition.
Benefits of Ostarine:
- Reduced liver toxicity:
Unlike Anavar, Ostarine is not a 17-alpha alkylated compound, which reduces the burden on the liver. - No aromatization:
Does not convert to estrogen, eliminating the risk of gynecomastia. - Ideal for beginners:
Has milder and more easily manageable side effects than Anavar, making it a popular choice for those new to SARMs. - Bone recovery:
Clinical studies have shown that Ostarine can promote bone health, an added benefit over Anavar.
ACP-105 vs Winstrol (Stanozolol)
Similarities:
Both are prized for their effects on muscle strength and density, making them especially useful for athletes and bodybuilders seeking performance and definition.
Benefits of ACP-105:
- Minor impact on cholesterol:
While Winstrol tends to reduce HDL cholesterol and increase LDL, ACP-105 has a much less pronounced effect on lipids. - Reduced joint pain:
Winstrol is known to cause joint dryness, an effect not seen with ACP-105. - Rapid muscle rebuilding:
Promotes effective body recomposition without the same risks of liver toxicity.
RAD-140 (Testolone) vs Testosterone
Similarities:
RAD-140 is often referred to as “the testosterone of SARMs” for its ability to improve strength, energy, and muscle. Both have significant anabolic effects, but RAD-140 stands out for its selectivity.
We specify that testosterone is the quintessential male hormone and its particular functions cannot be replaced by any other molecule
Benefits of RAD-140:
- Targeted effects:
Selectively binds to androgen receptors in muscle and bone tissues, reducing the risk of systemic side effects such as acne and hair loss and prostate damage. - No conversion to estrogen:
Eliminates the risk of gynecomastia and water retention associated with testosterone. - Ideal for definition:
Promotes dry, defined muscle growth, making it suitable for both cutting and body recomposition.
LGD-4033 (Ligandrol) vs Dianabol (Methandrostenolone)
Similarities:
LGD-4033 and Dianabol are both known to promote significant muscle gains and improve strength in a short time.
Benefits of LGD-4033:
- No aromatization:
Unlike Dianabol, it does not convert to estrogen, eliminating problems such as gynecomastia or water retention. - Lower liver toxicity:
Dianabol is highly hepatotoxic, while LGD-4033 is much milder in terms of side effects on the liver. - Quality gains:
LGD-4033 promotes true and sustainable muscle growth, and although it causes some water retention, it is in no way comparable to the water accumulation you get from using Dianabol.
Cardarin (Endurobol) vs Clenbuterol
Similarities:
Cardarina and Clenbuterol are popular for cutting due to their ability to increase endurance and promote fat loss.
Benefits of Cardarina:
- No nerve stimulation:
Unlike Clenbuterol, Cardarina does not affect the central nervous system, avoiding side effects such as tremors, anxiety, or tachycardia. - Effects on lipid profile:
Improves cholesterol levels and reduces triglycerides, while Clenbuterol may have adverse effects on the cardiovascular system. - Prolonged endurance:
Significantly increases aerobic capacity without requiring frequent cycling.
LGD-3303 vs Deca-Durabolin (Nandrolone Decanoate).
Similarities:
Both promote muscle growth and joint health, making them useful for athletes who need support during intense workouts.
Benefits of LGD-3303:
- Reduced androgenic effects:
Unlike Deca-Durabolin, it does not cause side effects such as acne, hair loss, or excessive testosterone suppression. - Clean muscle gains:
LGD-3303 promotes muscle growth without the water retention associated with Deca. - Focus on bone health:
Ideal for those seeking long-term improvement in bone density. - No increase in prolactin:
Nandrolone is known to cause (even very marked) increases in prolactin, with very significant side effects such as the notorious “Deca-Dick” (impotence).
YK-11 vs Trenbolone
Similarities:
YK-11 and Trenbolone share an extraordinary ability to promote muscle growth.
ùThe main difference lies in their mode of action: YK-11 inhibits myostatin, while Trenbolone acts through intense androgenic activity.
Benefits of YK-11:
- Less systemic toxicity:
Trenbolone can be extremely harmful to the cardiovascular system and liver, while YK-11 has a safer profile. - No Roid Rage:
Trenbolone is known to cause mental side effects, such as the famous “Roid Rage.” - Improved tolerance:
Side effects, when managed properly, are less severe than Trenbolone.
S-23 vs Masteron
Similarities:
Both are prized for their ability to improve muscle definition and reduce body fat, making them ideal for cutting cycles.
Benefits of S-23:
- Extreme definition:
Promotes sculpted, well-defined muscles, with effects visible within the first few weeks of use. - Androgen control:
Targeted androgenic effects that avoid Masteron’s side effects, such as hair loss. - Rapid gains:
Increases muscle density without water retention.
However, it is crucial to emphasize that SARMs are not without risks.
Possible side effects include suppression of natural testosterone, alterations in cholesterol levels, and, in some cases, effects on the liver.
The extent of these effects depends on the type of SARM used, the dosage, and the duration of the cycle. For this reason, the use of SARMs requires conscious and responsible handling.
A crucial component of safe use of SARMs is the adoption of appropriate post-cycle therapy (PCT).
After a cycle of SARMs, the body may need support to restore natural hormonal balance, preventing problems such as fatigue, loss of muscle mass, and decreased libido.
Not only does PCT help minimize side effects, but it also helps preserve the results achieved during the cycle.
In addition, it is important to educate yourself about your chosen product and your health condition before starting a cycle. Consulting a professional practitioner or physician experienced in supplements can make the difference between a positive experience and potential health risks.
The key to maximizing the benefits of SARMs while minimizing the risks lies in awareness and responsibility.
