Description
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Peptide 5-amino-1MQ is a molecule that blocks the activity of an enzyme called nicotinamide N-methyltransferase (NNMT).
NNMT plays a very important role in metabolism and energy production and is predominantly active in adipose tissue
By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a central cofactor for cellular metabolism, thereby increasing the metabolic rate and activating a gene called sirtuin-1 (SIRT1).
SIRT1 is also known as the “longevity gene” because of its role in reducing the risk of:
- Diabetes
- Obesity
- Metabolic syndrome
- Arteriosclerosis
- Cardiovascular disease
- Kidney diseases
- Liver diseases
- Neurodegenerative diseases and cancer.
According to research, mice treated with 5-amino-1MQ showed a 7 percent reduction in body mass without any change in food intake, compared with the control group.
The research showed that inhibition of the NNMT enzyme can help reduce both the number and size of adipocytes (i.e., fat cells).
This means that NNMT enzyme in effect activates slimming.
It is not easy to control or reverse excess weight and obesity because of changes in metabolism as we age.
These changes affect the body’s ability to break down fat stores to turn it into energy.
As a result, it can be more difficult to lose weight over time regardless of diet or activity levels.
The enzyme Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that regulates cellular energy balance.
It plays the role of a catalyst in methylation, one of the ways in which the liver metabolizes certain compounds.
NNMT predominantly active in adipose tissue.
5-amino 1MQ may also increase wellbeing (general well-being).
People taking 5-amino 1MQ peptide report experiencing less body pain, more energy, and better concentration.
In summary, based on recent studies, 5-amino 1MQ inhibits NNMT activity, which may prevent fat accumulation, increase cellular metabolism, and reduce fat cells.